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These observations add support to our previous conclusion that ADAM12 inhibits cell migration mediated by the α4β1 but not by the α5β1 integrin. As seen in Figure 3, with cells expressing both the α4β1 and α5β1 integrins (CHO-α4/GFP), ADAM12 inhibited cell migration on the α4β1-specific substrate in both transwell (Figure 3A) and scratch wound (Figures 3B and 4A) assays. Collectively, the results presented in Figure 2 (using two different cell migration assays) indicate that ADAM12 inhibits cell migration on full-length https://www.hierrosyacerosconil.com/ FN mediated by the α4β1 but not by the α5β1 integrin. In this study we provide the first evidence that ADAMs can selectively modulate integrin-mediated cell migration.
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Moreover, this pattern correlates with the selective adhesive activity of the ADAM12 disintegrin domain (Figure 1). For scratch wound assays, 24-well dishes were precoated with 10 μg/ml FN, and migration assays were conducted as described in Materials and Methods. Cells were either mock transfected or transfected to express full-length ADAM12, and transwell migration assays (A, C, E, and G) or scratch wound assays (B, D, F, and H) were conducted 24 h after transfection. Cells expressing α4β1 but not α5β1 integrin bind to recombinant ADAM12 disintegrin domain. A previous study demonstrated that GFP-tagged α4 integrin behaves like untagged α4 integrin (Pinco et al., 2002). Transwell migration assays were performed as described previously (Liu et al., 1999), with the following modifications.
Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family MembersV⃞
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